Schedule Jul 24, 2001
Single Cell Dynamics
Dr. David Kleinfeld
The goal is to review basic neuronal and synaptic physiology with an emphasis on common principles and modern analysis techniques. The basis of action potential generation, the control of firing properties with a plethora of channels, and the reduction of single cell dynamics to low dimensional systems will be presented, along with system identification of cell parameters through experimentation. Diffusion and chemical waves as a means of local computation and control in neuronal processes will be addressed. The dynamic properties of synapses, particularly with regard to short-term plasticity, are viewed both from a biophysical and a functional perspective. Emphasis is placed on the role of genetics and chemical networks in maintaining synaptic function. Lastly, the general issue of cell homeostasis is considered, with a discussion of mechanisms to maintain cell parameters like threshold levels and gain.

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